Translate formulae into processes

I need the reaction-to-process translation for scale-up of compound B12 ready for the pilot team. Take the bench protocol with stoichiometries, solvent volumes, and temperature ramps, convert quantities for a 50‑litre run, flag any steps where heat transfer or mixing will be non-linear at scale, and list the critical in-process controls for quality. Send this to Pilot Plant Lead Jorge Mendes and to QA by Monday morning.

Before I hand this to Jorge Mendes, make the scale-up sheet easy to approve: put the final yield and impurity risk summary at the top, highlight steps where the reaction time or quench is likely to change with batch size, and note which analytical checkpoints will convince QA to accept the run without stopping the line.

The bench protocol for B12 uses an ice-bath quench that controlled the exotherm at 200 mL scale. Jorge Mendes and I are worried that at 50 L the same quench will run away. I cannot tell if slower addition or a different quench solvent is safer given limited pilot plant time. What's the likeliest hazard and the safest next move to propose?

When we scale reactions from bench to pilot we keep getting surprises with heat release and poor mixing, costing runs and time. Which engineering or procedural habit should the chemists and pilot team adopt to reduce these surprises, and what single change will prevent most common scale-up failures?